Djulbegovic, Benjamin, Ambuj Kumar, Paul Glasziou, Branko Miladinovic, and Iain Chalmers. 2013. “Medical Research: Trial Unpredictability Yields Predictable Therapy Gains.”. Nature 500 (7463): 395-6.
Abstract
In decades of clinical-trial data, new treatments are better than standard ones just over half the time. That's as it should be, say Benjamin Djulbegovic and colleagues.