Genetically engineered mouse models of FK506-binding protein 5.
Gebru, Niat T, Shannon E Hill, and Laura J Blair. 2023. “Genetically Engineered Mouse Models of FK506-Binding Protein 5.”. Journal of Cellular Biochemistry.
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Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model.
Patel, Rekha S, Ashley Lui, Charles Hudson, Lauren Moss, Robert P Sparks, Shannon E Hill, Yan Shi, et al. 2023. “Small Molecule Targeting Long Noncoding RNA GAS5 Administered Intranasally Improves Neuronal Insulin Signaling and Decreases Neuroinflammation in an Aged Mouse Model.”. Scientific Reports 13 (1): 317.
Chaperoning activity of the cyclophilin family prevents tau aggregation.
Hill, Shannon E, Abigail R Esquivel, Santiago Rodriguez Ospina, Lauren M Rahal, Chad A Dickey, and Laura J Blair. 2022. “Chaperoning Activity of the Cyclophilin Family Prevents Tau Aggregation.”. Protein Science : A Publication of the Protein Society 31 (11): e4448.
Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice.
Criado-Marrero, Marangelie, Danielle M Blazier, Lauren A Gould, Niat T Gebru, Santiago Rodriguez Ospina, Debra S Armendariz, April L Darling, David Beaulieu-Abdelahad, and Laura J Blair. 2022. “Evidence Against a Contribution of the CCAAT-Enhancer Binding Protein Homologous Protein (CHOP) in Mediating Neurotoxicity in RTg4510 Mice.”. Scientific Reports 12 (1): 7372.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran, Leslie A, Andrii Kovalenko, Devon S Placides, Kevin Ratnasamy, Chao Ma, Jerry B Hunt, Huimin Liang, et al. 2021. “Aberrant AZIN2 and Polyamine Metabolism Precipitates Tau Neuropathology.”. The Journal of Clinical Investigation 131 (4).
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war.
Favretto, Filippo, David Flores, Jeremy D Baker, Timo Strohäker, Loren B Andreas, Laura J Blair, Stefan Becker, and Markus Zweckstetter. 2020. “Catalysis of Proline Isomerization and Molecular Chaperone Activity in a Tug-of-War.”. Nature Communications 11 (1): 6046.
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease.
Webster, Jack M, April L Darling, Vladimir N Uversky, and Laura J Blair. 2019. “Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease.”. Frontiers in Pharmacology 10: 1047.
Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
Huard, Dustin J E, Vincent M Crowley, Yuhong Du, Ricardo A Cordova, Zheying Sun, Moya O Tomlin, Chad A Dickey, et al. 2018. “Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.”. ACS Chemical Biology 13 (4): 933-41.
Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.
Sabbagh, Jonathan J, Sarah N Fontaine, Lindsey B Shelton, Laura J Blair, Jerry B Hunt, Bo Zhang, Joseph M Gutmann, Daniel C Lee, John D Lloyd, and Chad A Dickey. 2016. “Noncontact Rotational Head Injury Produces Transient Cognitive Deficits But Lasting Neuropathological Changes.”. Journal of Neurotrauma 33 (19): 1751-60.
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.
Fontaine, Sarah N, Dali Zheng, Jonathan J Sabbagh, Mackenzie D Martin, Dale Chaput, April Darling, Justin H Trotter, et al. 2016. “DnaJ/Hsc70 Chaperone Complexes Control the Extracellular Release of Neurodegenerative-Associated Proteins.”. The EMBO Journal 35 (14): 1537-49.