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81 results found

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet.

Publication: Journal Article

Whitehead, Anna K, Zhen Li, Kyle B LaPenna, Nour Abbes, Thomas E Sharp, David J Lefer, Eric Lazartigues, and Xinping Yue. 2024. “Cardiovascular Dysfunction Induced by Combined Exposure to Nicotine Inhalation and High-Fat Diet.”. American Journal of Physiology. Heart and Circulatory Physiology 326 (1): H278-H290.

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Publication: Journal Article

Wallner, Markus, Jason M Duran, Sadia Mohsin, Constantine D Troupes, Davy Vanhoutte, Giulia Borghetti, Ronald J Vagnozzi, et al. 2016. “Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.”. Circulation Research 119 (7): 865-79.

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

Publication: Journal Article

Li, Zhen, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S Li, et al. 2024. “Alcohol-Induced Gut Microbial Reorganization and Associated Overproduction of Phenylacetylglutamine Promotes Cardiovascular Disease.”. Nature Communications 15 (1): 10788.

Kiersten Gorse

Person: Advanced Research Scientist

Kiersten J. Gorse, B.S. Kiersten is an advanced research scientist in the Sharp laboratory at USF Morsani College of Medicine in Tampa, Florida, USA. Kiersten received her bachelor degree from Cornell University where she majored in animal sciences. She has more than a decade of biomedical research...

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.

Publication: Journal Article

Lefer, David J, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah, Zhen Li, and Traci T Goodchild. 2025. “Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure With Preserved Ejection Fraction.”. European Journal of Heart Failure.

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Thomas E. Sharp, III

Person: Principal Investigator

Tom is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the USF Morsani College of Medicine and a faculty member of the USF Health Heart Institute in Tampa, Florida, USA. He earned his Ph.D. from Temple University’s Lewis Katz School of Medicine, where he was...

2024 Nature Communications - ARTICLE

News: December 30, 2024

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in...

2024 Alcohol: Clinical & Experimental Research - COMMNETARY

News: August 14, 2024

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle. Originally, light-to-moderate alcohol consumption was believed to provide some protective effects on the cardiovascular system through its antioxidant properties and other constituents; this was...

2025 JACC: Basic to Translational Science - ARTICLE

News: August 18, 2025

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and diastolic dysfunction. We utilized a systems-biology approach to...