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Gaurav Choudhary, MD, FACC, FAHA
His research aims to improve outcomes in patients with pulmonary hypertension by discovering new therapeutic targets to mitigate pulmonary vascular remodeling and right heart failure by performing preclinical, clinical, and epidemiological studies. He is a co-investigator for our multiple-PI R01...
Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells.
Ma, Zhongcai, BongSook Jhun, and Chad K Oh. 2007. “Upstream Stimulating Factor-1 Mediates the E-Box-Dependent Transcriptional Repression of the Plasminogen Activator Inhibitor-1 Gene in Human Mast Cells.”. FEBS Letters 581 (23): 4485-90.
Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells.
Ma, Zhongcai, BongSook Jhun, Sandy Y Jung, and Chad K Oh. 2008. “Binding of Upstream Stimulatory Factor 1 to the E-Box Regulates the 4G/5G Polymorphism-Dependent Plasminogen Activator Inhibitor 1 Expression in Mast Cells.”. The Journal of Allergy and Clinical Immunology 121 (4): 1006-1012.e2.
VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.
Ha, Chang Hoon, Bong Sook Jhun, Hung-Ying Kao, and Zheng-Gen Jin. 2008. “VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiogenesis.”. Arteriosclerosis, Thrombosis, and Vascular Biology 28 (10): 1782-8.
Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.
Wang, Weiye, Chang Hoon Ha, Bong Sook Jhun, Chelsea Wong, Mukesh K Jain, and Zheng-Gen Jin. 2010. “Fluid Shear Stress Stimulates Phosphorylation-Dependent Nuclear Export of HDAC5 and Mediates Expression of KLF2 and ENOS.”. Blood 115 (14): 2971-9.
Mitochondrial dynamics in diabetes.
Yoon, Yisang, Chad A Galloway, Bong Sook Jhun, and Tianzheng Yu. 2011. “Mitochondrial Dynamics in Diabetes.”. Antioxidants & Redox Signaling 14 (3): 439-57.
Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress.
Galloway, Chad A, Hakjoo Lee, Souad Nejjar, Bong Sook Jhun, Tianzheng Yu, Wei Hsu, and Yisang Yoon. 2012. “Transgenic Control of Mitochondrial Fission Induces Mitochondrial Uncoupling and Relieves Diabetic Oxidative Stress.”. Diabetes 61 (8): 2093-104.
Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.
O-Uchi, Jin, Bong Sook Jhun, Shangcheng Xu, Stephen Hurst, Anna Raffaello, Xiaoyun Liu, Bing Yi, et al. 2014. “Adrenergic Signaling Regulates Mitochondrial Ca2+ Uptake through Pyk2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca2+ Uniporter.”. Antioxidants & Redox Signaling 21 (6): 863-79.
α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension.
Vang, Alexander, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R Morrison, Thomas J Mancini, Richard T Clements, et al. 2021. “α7 Nicotinic Acetylcholine Receptor Mediates Right Ventricular Fibrosis and Diastolic Dysfunction in Pulmonary Hypertension.”. JCI Insight 6 (12).