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Dr. Shannon Hill joins the Department of Chemistry at USF We are excited to announce that Dr. Shannon Hill has transitioned from our lab to open her own independent lab as a tenure-track Assistant Professor in the Department of Chemistry at the University of South Florida. We are excited to continue...

A Phase 3 Multi-Center Study to Evaluate the Safety and Efficacy of Subcutaneous Injections of Pegvaliase in Adolescent Subjects (Ages 12-17) with Phenylketonuria Featuring an Open-Label Randomized Two-Arm (Active vs. Diet-Only Control) Design ClinicalTrials.gov ID NCT05270837 Sponsor BioMarin...

Dr. Ava Nasrollahi published a new article entitled "laminins and the blood-brain barrier" in Matrix Biology.

Min, who recently graduated from her PhD together with Ava have identified novel markers for brain pericytes, specialized cells crucial for brain health and function. By generating a unique mouse model and employing advanced RNA sequencing, the team distinguished pericytes from similar vascular...

We are excited to welcome Trung to the Sharp Laboratory as a graduate student! Trung is a native Floridian, who received his undergradute degree from the University of Florida followed by a Master's from John's Hopkins University in Baltimore, MD. Trung has joined us as of Jan. 2024. Looking forward...

We are excited to welcome Kiersten to the Sharp Laboratory as an advanced research scientist! Kiersten is a native to Florida, who received her undergraduate degree from Cornell University. Kiersten has more than a decade of biomedical research experience. Kiersten has joined us as of Dec. 2023...

Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure with Preserved Ejection Fraction Aims - Overactivity of the sympathetic nervous system is a common underlying mechanism in development and progression of several heart failure with preserved...

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H 2S) bioavailability in HFpEF patients and 2 animal models: the "2-hit" L-NAME + high-fat...

This brand-new publication from the Swamynathan laboratory, spearheaded by Mehak Vohra and Simran Kumar, was supported by the rest of the team. In this paper, they used a novel mouse model and a variety of different assays to elucidate that the apicobasal polarity determinant Pard3 promotes corneal...