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Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.

Publication: Journal Article

Motawe, Zeinab Y, Forouzandeh Farsaei, Salma S Abdelmaboud, Javier Cuevas, and Jerome W Breslin. 2020. “Sigma-1 Receptor Activation-Induced Glycolytic ATP Production and Endothelial Barrier Enhancement.”. Microcirculation (New York, N.Y. : 1994) 27 (6): e12620.

Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels.

Publication: Journal Article

Jo, Michiko, Andrea N Trujillo, Ying Yang, and Jerome W Breslin. 2019. “Evidence of Functional Ryanodine Receptors in Rat Mesenteric Collecting Lymphatic Vessels.”. American Journal of Physiology. Heart and Circulatory Physiology 317 (3): H561-H574.

Sphingosine-1-phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol.

Publication: Journal Article

Alves, Natascha G, Sarah Y Yuan, and Jerome W Breslin. 2019. “Sphingosine-1-Phosphate Protects Against Brain Microvascular Endothelial Junctional Protein Disorganization and Barrier Dysfunction Caused by Alcohol.”. Microcirculation (New York, N.Y. : 1994) 26 (1): e12506.

Breslin Lab

Our laboratory investigates problems pertaining to microvascular dysfunction and lymphatic disease.

Research on excessively “leaky” microvessels may lead to better trauma treatment

News: August 24, 2016

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August 11, 2020 Turpis cursus in hac habitasse platea dictumst quisque sagittis purus. Semper feugiat nibh sed pulvinar proin gravida hendrerit lectus. Optio vel quisquam nobis molestiae iste. Quia inventore est libero amet ea explicabo. Assumenda eligendi repudiandae autem omnis pariatur quam omnis...

The Mechanisms of Cellular Plasticity in Collecting Duct Cells: Intermediate Cell Type and Notch-mediated Transdifferentiation

Publication: Journal Article

Klemens, CA, A. Staruschenko, and O. Palygin. 2021. “The Mechanisms of Cellular Plasticity in Collecting Duct Cells: Intermediate Cell Type and Notch-Mediated Transdifferentiation”. Function (Oxf). 32 (7): 1789-1804.

Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a "Two-Hit" Murine Model

Publication: Journal Article

LaPenna, KB., Z. Li, JE. Doiron, TE. Sharp, H. Xia, K. Moles, K. Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a ‘Two-Hit’ Murine Model”. Journal of the American Heart Association.

Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure

Publication: Journal Article

Li, Z., H. Xia, TE. Sharp, KB. LaPenna, A. Katsouda, JW. Elrod, J. Pfeilschifter, et al. 2023. “Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure”. Circulation Research.

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation.

Publication: Journal Article

Tatavosian, Roubina, Micah G Donovan, Matthew D Galbraith, Huy N Duc, Maria M Szwarc, Molishree U Joshi, Amy Frieman, et al. 2023. “Cell Differentiation Modifies the P53 Transcriptional Program through a Combination of Gene Silencing and Constitutive Transactivation.”. Cell Death and Differentiation 30 (4): 952-65.