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Kappa-opioid receptor antagonism in the nucleus accumbens shell distinguishes escalated alcohol consumption and negative affective-like behavior from physiological withdrawal in alcohol-dependence.
Lepreux, Gaetan, Angela M Henricks, Gengze Wei, Bok Soon Go, Chloe M Erikson, Rachel M Abella, Amy Pham, and Brendan M Walker. 2024. “Kappa-Opioid Receptor Antagonism in the Nucleus Accumbens Shell Distinguishes Escalated Alcohol Consumption and Negative Affective-Like Behavior from Physiological Withdrawal in Alcohol-Dependence.”. Pharmacology, Biochemistry, and Behavior 243: 173840.
Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.
Lepreux, Gaetan, Grace E Shinn, Gengze Wei, Azra Suko, George Concepcion, Sunil Sirohi, Bok Soon Go, Michael R Bruchas, and Brendan M Walker. 2023. “Recapitulating Phenotypes of Alcohol Dependence via Overexpression of Oprk1 in the Ventral Tegmental Area of Non-Dependent TH::Cre Rats.”. Neuropharmacology 228: 109457.
Dysregulated kappa-opioid receptors in the medial prefrontal cortex contribute to working memory deficits in alcohol dependence.
Wei, Gengze, Sunil Sirohi, and Brendan M Walker. 2022. “Dysregulated Kappa-Opioid Receptors in the Medial Prefrontal Cortex Contribute to Working Memory Deficits in Alcohol Dependence.”. Addiction Biology 27 (2): e13138.
Species differences in the effects of the κ-opioid receptor antagonist zyklophin.
Sirohi, Sunil, Jane Aldrich V, and Brendan M Walker. 2016. “Species Differences in the Effects of the κ-Opioid Receptor Antagonist Zyklophin.”. Alcohol (Fayetteville, N.Y.) 51: 43-9.
Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.
Walker, Brendan M, Glenn R Valdez, Jay P McLaughlin, and Georgy Bakalkin. 2012. “Targeting Dynorphin/Kappa Opioid Receptor Systems to Treat Alcohol Abuse and Dependence.”. Alcohol (Fayetteville, N.Y.) 46 (4): 359-70.
κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats.
Nealey, Kathryn A, Alexander W Smith, Seth M Davis, Daniel G Smith, and Brendan M Walker. 2011. “κ-Opioid Receptors Are Implicated in the Increased Potency of Intra-Accumbens Nalmefene in Ethanol-Dependent Rats.”. Neuropharmacology 61 (1-2): 35-42.
Milk consumption during adolescence decreases alcohol drinking in adulthood.
Pian, Jerry P, Jose R Criado, Brendan M Walker, and Cindy L Ehlers. 2009. “Milk Consumption During Adolescence Decreases Alcohol Drinking in Adulthood.”. Pharmacology, Biochemistry, and Behavior 94 (1): 179-85.