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Sharp Laboratory - University South Florida

News: June 01, 2020

The Sharp Laboratory has joined USF, Morsani College of Medicine, Department of Molecular Pharmacology and Physiology. We will reside at the downtown campus - USF MDD. We are also affiliated with the USFHealth Heart Institute. As the laboratory develops and grows we will seek exceptionally motivated...

Common Heart Failure with Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics

Publication: Journal Article

Fenwick, AJ., VP. Jani, DB. Foster, TE. Sharp, TT. Goodchild, KB. LaPenna, JE. Doiron, et al. 2024. “Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics”. Journal of the American Heart Association.

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high fat diet

Publication: Journal Article

Whitehead, A., Z. Li, KB. LaPenna, TE. Sharp, DJ. Lefer, E. Lazartigues, and X. Yue. 2023. “Cardiovascular Dysfunction Induced by Combined Exposure to Nicotine Inhalation and High Fat Diet”. American Journal of Physiology-Heart and Circulatory Physiology.

Alpha7 Nicotinic Acetylcholine Receptor Mediates Chronic Nicotine Inhalation-Induced Cardiopulmonary Dysfunction

Publication: Journal Article

Whitehead, A., N. Fried, Z. Li, K. Neelamegan, C. Pearson, KB. LaPenna, Sharp TE., et al. 2022. “Alpha7 Nicotinic Acetylcholine Receptor Mediates Chronic Nicotine Inhalation-Induced Cardiopulmonary Dysfunction”. Clinical Science.

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle

Publication: Journal Article

Sharp, Thomas, and Thanh Trung Van. 2024. “Thromboxane A2 Blockade Attenuates Ethanol-Induced Myocardial Inflammation: Sipping from the Same Bottle”. Alcohol: Clinical & Experimental Research.

Novel Gottingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities

Publication: Journal Article

Sharp, TE., A. Scarborough, Z. Li, DJ. Polhemus, H. Hidalgo, JD. Schumacher, TR. Matsuura, et al. 2022. “Novel Gottingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities”. JACC: Basic to Translational Science.

2024 AMERICAN HEART ASSOCIATION Basic Cardiovascular (BCVS) Scientific Sessions

News: July 22, 2024

Abstract Presented: "Gut Microbial Metabolite Phenylacetylglutamine Leads to Cardiomyocyte Hypercontractility and Vascular Endothelial Cell Activation."

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We are located in the USF Health Heart Institute at the University of South Florida, Morsani College of Medicine, Tampa, FL. Our academic affiliation is in the Department of Molecular Pharmacology and Physiology. Our laboratory is focused on discovery-based, hypothesis-driven biomedical research...

Sharp Lab

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