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166 results found

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.

Publication: Journal Article

LaPenna, Kyle B, Zhen Li, Jake E Doiron, Thomas E Sharp, Huijing Xia, Karl Moles, Kashyap Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a ‘2-Hit’ Murine Model.”. Journal of the American Heart Association 12 (4): e028480.

Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

Publication: Journal Article

Sharp, Thomas E, Giana J Schena, Alexander R Hobby, Timothy Starosta, Remus M Berretta, Markus Wallner, Giulia Borghetti, et al. 2017. “Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.”. Circulation Research 121 (11): 1263-78.

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.

Publication: Journal Article

Bradley, Jessica M, Pablo Spaletra, Zhen Li, Thomas E Sharp, Traci T Goodchild, Laura G Corral, Leah Fung, et al. 2018. “A Novel Fibroblast Activation Inhibitor Attenuates Left Ventricular Remodeling and Preserves Cardiac Function in Heart Failure.”. American Journal of Physiology. Heart and Circulatory Physiology 315 (3): H563-H570.

Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.

Publication: Journal Article

Organ, Chelsea L, Zhen Li, Thomas E Sharp, David J Polhemus, Nilaksh Gupta, Traci T Goodchild, W H Wilson Tang, Stanley L Hazen, and David J Lefer. 2020. “Nonlethal Inhibition of Gut Microbial Trimethylamine N-Oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.”. Journal of the American Heart Association 9 (10): e016223.

Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

Publication: Journal Article

Polhemus, David J, Rishi K Trivedi, Thomas E Sharp, Zhen Li, Traci T Goodchild, Amy Scarborough, Geoffrey de Couto, Eduardo Marbán, and David J Lefer. 2019. “Repeated Cell Transplantation and Adjunct Renal Denervation in Ischemic Heart Failure: Exploring Modalities for Improving Cell Therapy Efficacy.”. Basic Research in Cardiology 114 (2): 9.

Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.

Publication: Journal Article

Taghavi, Sharven, Thomas E Sharp, Jason M Duran, Catherine A Makarewich, Remus M Berretta, Tim Starosta, Hajime Kubo, Mary Barbe, and Steven R Houser. 2015. “Autologous C-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit As Compared to C-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.”. Clinical and Translational Science 8 (5): 425-31.

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.

Publication: Journal Article

Li, Zhen, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, Jake E Doiron, Huijing Xia, et al. 2024. “Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure With Preserved Ejection Fraction.”. BioRxiv : The Preprint Server for Biology.

January 2025-Dr. Yao received the Renato Iozzo Award from American Society of Matrix Biology

News: January 13, 2025

Dr. Yao has been selected as the Renato Iozzo Awardee from the American Society of Matrix Biology. Congratulations!

Alejandra Juan Palencia

she/her

Person: Graduate Research Assistant

Originally from Colombia, Alejandra has a strong interest in neurodegenerative diseases and the mechanisms underlying their progression. She earned her bachelor's in Pharmacy in Spain, where she began her training in neuroscience research. During this time, she developed a deeper curiosity about how...