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Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.

Publication: Journal Article

Sharp, Thomas E, Hajime Kubo, Remus M Berretta, Timothy Starosta, Markus Wallner, Giana J Schena, Alexander R Hobby, et al. 2017. “Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.”. JACC. Basic to Translational Science 2 (6): 669-83.

Acute right heart failure after hemorrhagic shock and trauma pneumonectomy-a management approach: A blinded randomized controlled animal trial using inhaled nitric oxide.

Publication: Journal Article

Lubitz, Andrea L, Lars O Sjoholm, Amy Goldberg, Abhijit Pathak, Thomas Santora, Thomas E Sharp, Markus Wallner, et al. 2017. “Acute Right Heart Failure After Hemorrhagic Shock and Trauma Pneumonectomy-a Management Approach: A Blinded Randomized Controlled Animal Trial Using Inhaled Nitric Oxide.”. The Journal of Trauma and Acute Care Surgery 82 (2): 243-51.

Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.

Publication: Journal Article

Gross, Polina, Nicolas Honnorat, Erdem Varol, Markus Wallner, Danielle M Trappanese, Thomas E Sharp, Timothy Starosta, et al. 2016. “Nuquantus: Machine Learning Software for the Characterization and Quantification of Cell Nuclei in Complex Immunofluorescent Tissue Images.”. Scientific Reports 6: 23431.

2025 AJP:Heart and Circulatory Physiology - ARTICLE

News: January 28, 2025

"Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment" Swine are increasingly utilized in cardiovascular research due to their anatomical and physiological similarities to humans, particularly for studying diastolic dysfunction. While...

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Early Renal Denervation Attenuates Cardiorenal Dysfunction in Heart Failure with Preserved Ejection Fraction

Publication: Journal Article

Doiron, JE., Z. Li, TE. Sharp, KB. LaPenna, K. Koul, AJ. Malek, SJ. Shah, et al. 2024. “Early Renal Denervation Attenuates Cardiorenal Dysfunction in Heart Failure With Preserved Ejection Fraction”. Journal of the American Heart Association.

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure

Publication: Journal Article

Li, Z., H. Xia, TE. Sharp, KB. LaPenna, JW. Elrod, JW. Calvert, FN. Salloumn, et al. 2022. “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure”. Circulation Research.

Adjunctive Therapy with an Oral H2S Donor Provides Additional Therapeutic Benefit Beyond SGLT2 Inhibition in Cardiometabolic HFpEF

Publication: Journal Article

Doiron, JE., H. Xio, X. Yu, AR. Nevins, KB. LaPenna, TE. Sharp, TT. Goodchild, et al. 2024. “Adjunctive Therapy With an Oral H2S Donor Provides Additional Therapeutic Benefit Beyond SGLT2 Inhibition in Cardiometabolic HFpEF”. British Journal of Pharmacology.

2024 CARDIOVASCULAR RESEARCH FOUNDATION TCT Conference

News: October 28, 2024

Abstract Presented: "Ultrasound Renal Denervation Protects the Ischemic-Reperfused Myocardium in a swine Model of Hypertension and Dyslipidemia"

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.

Publication: Journal Article

Fenwick, Axel J, Vivek P Jani, Brian Foster, Thomas E Sharp, Traci T Goodchild, Kyle LaPenna, Jake E Doiron, et al. 2024. “Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.”. Journal of the American Heart Association 13 (2): e032037.