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Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.

Publication: Journal Article

Fenwick, Axel J, Vivek P Jani, Brian Foster, Thomas E Sharp, Traci T Goodchild, Kyle LaPenna, Jake E Doiron, et al. 2024. “Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.”. Journal of the American Heart Association 13 (2): e032037.

Renal Denervation to Treat Heart Failure.

Publication: Journal Article

Sharp, Thomas E, and David J Lefer. 2021. “Renal Denervation to Treat Heart Failure.”. Annual Review of Physiology 83: 39-58.

Angiotensin Receptor-Neprilysin Inhibitors Emerge as Potential Treatment for Acute Myocardial Infarction.

Publication: Journal Article

Lefer, David J, and Thomas E Sharp. 2018. “Angiotensin Receptor-Neprilysin Inhibitors Emerge As Potential Treatment for Acute Myocardial Infarction.”. Journal of the American College of Cardiology 72 (19): 2357-59.

Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?

Publication: Journal Article

Sharp, Thomas E, David J Lefer, and Traci T Goodchild. 2021. “Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?”. JACC. Basic to Translational Science 6 (4): 397-99.

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.

Publication: Journal Article

Sharp, Thomas E, Amy L Scarborough, Zhen Li, David J Polhemus, Hunter A Hidalgo, Jeffery D Schumacher, Timothy R Matsuura, et al. 2021. “Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.”. JACC. Basic to Translational Science 6 (2): 154-70.

Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction.

Publication: Journal Article

Hobby, Alexander R H, Thomas E Sharp, Remus M Berretta, Giulia Borghetti, Eric Feldsott, Sadia Mohsin, and Steven R Houser. 2019. “Cortical Bone-Derived Stem Cell Therapy Reduces Apoptosis After Myocardial Infarction.”. American Journal of Physiology. Heart and Circulatory Physiology 317 (4): H820-H829.

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).

Publication: Journal Article

Gibb, Andrew A, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Carmen Choya-Foces, Jake E Doiron, et al. 2024. “Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism As Key Contributors to Heart Failure With Preserved Ejection Fraction (HFpEF).”. BioRxiv : The Preprint Server for Biology.

Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

Publication: Journal Article

Mohsin, Sadia, Constantine D Troupes, Timothy Starosta, Thomas E Sharp, Elorm J Agra, Shavonn Smith, Jason M Duran, et al. 2015. “Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.”. Circulation Research 117 (12): 1024-33.

2025 AHA BCVS - CONFERENCE: Dr. Sharp speaks on Renal Denervation to Treat Heart Failure

News: July 23, 2025

Dr. Sharp speaks at the 2025 American Heart Association, Basic Cardiovascular Sciences Scientific Session, Baltimore, MD. AHA BCVS is one of the largest meetings globally dedicated to fundamental and translational research in cardiovascular science. The BCVS Scientific Sessions is a unique and...

2025 Circulation Research - ARTICLE

News: September 17, 2025

Background: Recent studies suggest aberrant elevation of iNOS (inducible NO synthase) expression and excessive protein s-nitrosylation promote the pathogenesis of heart failure with preserved ejection fraction (HFpEF). However, the interplay between NO bioavailability, enzymatic regulation of...