Dr. Magadum's laboratory is developing next-generation mRNA therapeutics for cardiovascular diseases and repair. His research has identified several novel mRNA-delivered gene targets that promote cardiac repair and cardiomyocyte proliferation, enhance angiogenesis, and inhibit maladaptive cardiac remodeling processes such as cell death, hypertrophy, oxidative stress, and fibrosis. A central theme of our research is understanding how metabolic and signaling pathways can be harnessed to enhance cardiac repair like serine synthesis pathway. By integrating molecular biology with in vivo mouse models of heart injury, we evaluate therapeutic efficacy using advanced imaging, lineage tracing, and functional assays.
Dr. Magadum's lab continues to develop innovative delivery systems for mRNA to achieve targeted and efficient expression in the heart while minimizing off-target effects. Our work bridges fundamental biology and translational medicine, with the goal of creating clinically relevant mRNA-based therapies that can restore heart function and improve patient outcomes.