Halade Lab - Lipid Metabolism & Chronic Inflammation Research

The Halade Lab at the University of South Florida studies how lipid metabolism drives chronic inflammation in cancer and heart disease. We explore immune responses, bioactive lipids, and inflammatory mediators to improve heart and metabolic health, aiming for therapeutic advancements through lifestyle-based interventions.

Research Areas

Chronic Inflammation and Heart Failure

Our research focuses on understanding how chronic inflammation and metabolic dysregulation contribute to heart failure. We study heart failure's etiology, measure inflammatory mediators affecting cardiac repair, explore the role of resolution receptors in inflammation resolution, and translate findings for therapeutic use, considering key risk factors like obesity, diabetes, and aging.

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Ganesh Halade

PhD

Principal Investigator

Meet the Team

Featured Publications

Halade, Ganesh V., Vasundhara Kain, Xavier De La Rosa, and Merry L Lindsey. 2022. “Metabolic Transformation of Fat in Obesity Determines the Inflammation Resolving Capacity of Splenocardiac and Cardiorenal Networks in Heart Failure”. Heart and Circulator Physiology 322 (1): 953-70.

Publisher's Version
Halade, Ganesh V., and Dae Hyun Lee. 2022. “Inflammation and Resolution Signaling in Cardiac Repair and Heart Failure”. EBioMedicine 79.

Publisher's Version
Kain, Vasundhara, Jeevan Kumar Jadapalli, Bochra Tourki, and Ganesh V. Halade. 2019. “Inhibition of FPR2 Impaired Leukocytes Recruitment and Elicited Non-Resolving Inflammation in Acute Heart Failure”. Pharmacological Research 146.

Publisher's Version
Halade, Ganesh V., Paul C Norris, Vasundhara Kain, Charles N Serhan, and Kevin A Ingle. 2018. “Splenic Leukocytes Define the Resolution of Inflammation in Heart Failure”. Science Signaling 11.

Publisher's Version

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