Mishra, Jyotsna, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, and Shey-Shing Sheu. 2017. “The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.”. Handbook of Experimental Pharmacology 240: 129-56.
Abstract
Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.