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α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension.

Publication: Journal Article

Vang, Alexander, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R Morrison, Thomas J Mancini, Richard T Clements, et al. 2021. “α7 Nicotinic Acetylcholine Receptor Mediates Right Ventricular Fibrosis and Diastolic Dysfunction in Pulmonary Hypertension.”. JCI Insight 6 (12).

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules.

Publication: Journal Article

Kazmirczak, Felipe, Lynn M Hartweck, Neal T Vogel, Jenna B Mendelson, Anna K Park, Rashmi M Raveendran, Jin O-Uchi, Bong Sook Jhun, Sasha Z Prisco, and Kurt W Prins. 2023. “Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism And Microtubules.”. JACC. Basic to Translational Science 8 (3): 239-54.

Congrats on Acceptance to Graduate School

News: March 06, 2026

Lily, a Research Scientist, has been accepted into the PhD Program in Medical Sciences at the USF Health Morsani College of Medicine. Congratulations on her well-deserved success! Wishing her continued success and progress throughout her academic journey.

Jhun Lab

Collaborations

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Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways.

Publication: Journal Article

Hong, F, S J Kwon, B S Jhun, S S Kim, J Ha, S J Kim, N W Sohn, C Kang, and I Kang. 2001. “Insulin-Like Growth Factor-1 Protects H9c2 Cardiac Myoblasts from Oxidative Stress-Induced Apoptosis via Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Pathways.”. Life Sciences 68 (10): 1095-105.

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

Publication: Journal Article

Ha, Chang Hoon, Ji Young Kim, Jinjing Zhao, Weiye Wang, Bong Sook Jhun, Chelsea Wong, and Zheng Gen Jin. 2010. “PKA Phosphorylates Histone Deacetylase 5 and Prevents Its Nuclear Export, Leading to the Inhibition of Gene Transcription and Cardiomyocyte Hypertrophy.”. Proceedings of the National Academy of Sciences of the United States of America 107 (35): 15467-72.

Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts.

Publication: Journal Article

O-Uchi, Jin, Bong Sook Jhun, Stephen Hurst, Sara Bisetto, Polina Gross, Ming Chen, Sarah Kettlewell, et al. 2013. “Overexpression of Ryanodine Receptor Type 1 Enhances Mitochondrial Fragmentation and Ca2+-Induced ATP Production in Cardiac H9c2 Myoblasts.”. American Journal of Physiology. Heart and Circulatory Physiology 305 (12): H1736-51.

The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.

Publication: Journal Article

Mishra, Jyotsna, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, and Shey-Shing Sheu. 2017. “The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.”. Handbook of Experimental Pharmacology 240: 129-56.

Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes.

Publication: Journal Article

Jhun, Bong Sook, Jin O-Uchi, Stephanie M Adaniya, Thomas J Mancini, Jessica L Cao, Michelle E King, Amy K Landi, et al. 2018. “Protein Kinase D Activation Induces Mitochondrial Fragmentation and Dysfunction in Cardiomyocytes.”. The Journal of Physiology 596 (5): 827-55.