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Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.

Publication: Journal Article

Gross, Polina, Nicolas Honnorat, Erdem Varol, Markus Wallner, Danielle M Trappanese, Thomas E Sharp, Timothy Starosta, et al. 2016. “Nuquantus: Machine Learning Software for the Characterization and Quantification of Cell Nuclei in Complex Immunofluorescent Tissue Images.”. Scientific Reports 6: 23431.

2025 Clinical and Translational Science - ARTICLE: Brief Report

News: July 31, 2025

Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study Acute myocardial infarction (AMI) patients typically present with a constellation of one or more risk factors including hypertension...

2025 AJP:Heart and Circulatory Physiology - ARTICLE

News: January 28, 2025

Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment Swine are increasingly utilized in cardiovascular research due to their anatomical and physiological similarities to humans, particularly for studying diastolic dysfunction. While...

Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.

Publication: Journal Article

Li, Zhen, Huijing Xia, Thomas E Sharp, Kyle B LaPenna, Antonia Katsouda, John W Elrod, Josef Pfeilschifter, et al. 2023. “Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.”. Circulation Research 132 (2): 154-66.

BAG3: a new player in the heart failure paradigm.

Publication: Journal Article

Knezevic, Tijana, Valerie D Myers, Jennifer Gordon, Douglas G Tilley, Thomas E Sharp, JuFang Wang, Kamel Khalili, Joseph Y Cheung, and Arthur M Feldman. 2015. “BAG3: a New Player in the Heart Failure Paradigm.”. Heart Failure Reviews 20 (4): 423-34.

Combination Cell Therapy for Ischemic Cardiomyopathy: Is the Whole Greater Than Sum of Its Parts?

Publication: Journal Article

Recchia, Fabio A, and Thomas E Sharp. 2017. “Combination Cell Therapy for Ischemic Cardiomyopathy: Is the Whole Greater Than Sum of Its Parts?”. Journal of the American College of Cardiology 70 (20): 2516-18.

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.

Publication: Journal Article

LaPenna, Kyle B, Zhen Li, Jake E Doiron, Thomas E Sharp, Huijing Xia, Karl Moles, Kashyap Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a ‘2-Hit’ Murine Model.”. Journal of the American Heart Association 12 (4): e028480.

Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

Publication: Journal Article

Sharp, Thomas E, Giana J Schena, Alexander R Hobby, Timothy Starosta, Remus M Berretta, Markus Wallner, Giulia Borghetti, et al. 2017. “Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.”. Circulation Research 121 (11): 1263-78.

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.

Publication: Journal Article

Bradley, Jessica M, Pablo Spaletra, Zhen Li, Thomas E Sharp, Traci T Goodchild, Laura G Corral, Leah Fung, et al. 2018. “A Novel Fibroblast Activation Inhibitor Attenuates Left Ventricular Remodeling and Preserves Cardiac Function in Heart Failure.”. American Journal of Physiology. Heart and Circulatory Physiology 315 (3): H563-H570.

Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.

Publication: Journal Article

Organ, Chelsea L, Zhen Li, Thomas E Sharp, David J Polhemus, Nilaksh Gupta, Traci T Goodchild, W H Wilson Tang, Stanley L Hazen, and David J Lefer. 2020. “Nonlethal Inhibition of Gut Microbial Trimethylamine N-Oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.”. Journal of the American Heart Association 9 (10): e016223.