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Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.

Publication: Journal Article

Gross, Polina, Nicolas Honnorat, Erdem Varol, Markus Wallner, Danielle M Trappanese, Thomas E Sharp, Timothy Starosta, et al. 2016. “Nuquantus: Machine Learning Software for the Characterization and Quantification of Cell Nuclei in Complex Immunofluorescent Tissue Images.”. Scientific Reports 6: 23431.

2025 AJP:Heart and Circulatory Physiology - ARTICLE

News: January 28, 2025

"Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment" Swine are increasingly utilized in cardiovascular research due to their anatomical and physiological similarities to humans, particularly for studying diastolic dysfunction. While...

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.

Publication: Journal Article

Fenwick, Axel J, Vivek P Jani, Brian Foster, Thomas E Sharp, Traci T Goodchild, Kyle LaPenna, Jake E Doiron, et al. 2024. “Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.”. Journal of the American Heart Association 13 (2): e032037.

Renal Denervation to Treat Heart Failure.

Publication: Journal Article

Sharp, Thomas E, and David J Lefer. 2021. “Renal Denervation to Treat Heart Failure.”. Annual Review of Physiology 83: 39-58.

Angiotensin Receptor-Neprilysin Inhibitors Emerge as Potential Treatment for Acute Myocardial Infarction.

Publication: Journal Article

Lefer, David J, and Thomas E Sharp. 2018. “Angiotensin Receptor-Neprilysin Inhibitors Emerge As Potential Treatment for Acute Myocardial Infarction.”. Journal of the American College of Cardiology 72 (19): 2357-59.

Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?

Publication: Journal Article

Sharp, Thomas E, David J Lefer, and Traci T Goodchild. 2021. “Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?”. JACC. Basic to Translational Science 6 (4): 397-99.

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.

Publication: Journal Article

Sharp, Thomas E, Amy L Scarborough, Zhen Li, David J Polhemus, Hunter A Hidalgo, Jeffery D Schumacher, Timothy R Matsuura, et al. 2021. “Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.”. JACC. Basic to Translational Science 6 (2): 154-70.

Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction.

Publication: Journal Article

Hobby, Alexander R H, Thomas E Sharp, Remus M Berretta, Giulia Borghetti, Eric Feldsott, Sadia Mohsin, and Steven R Houser. 2019. “Cortical Bone-Derived Stem Cell Therapy Reduces Apoptosis After Myocardial Infarction.”. American Journal of Physiology. Heart and Circulatory Physiology 317 (4): H820-H829.

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).

Publication: Journal Article

Gibb, Andrew A, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Carmen Choya-Foces, Jake E Doiron, et al. 2024. “Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism As Key Contributors to Heart Failure With Preserved Ejection Fraction (HFpEF).”. BioRxiv : The Preprint Server for Biology.

Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

Publication: Journal Article

Mohsin, Sadia, Constantine D Troupes, Timothy Starosta, Thomas E Sharp, Elorm J Agra, Shavonn Smith, Jason M Duran, et al. 2015. “Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.”. Circulation Research 117 (12): 1024-33.