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2025 AHA BCVS - CONFERENCE: Dr. Sharp speaks on Renal Denervation to Treat Heart Failure

News: July 23, 2025

Dr. Sharp speaks at the 2025 American Heart Association, Basic Cardiovascular Sciences Scientific Session, Baltimore, MD. AHA BCVS is one of the largest meetings globally dedicated to fundamental and translational research in cardiovascular science. The BCVS Scientific Sessions is a unique and...

Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.

Publication: Journal Article

Li, Zhen, Huijing Xia, Thomas E Sharp, Kyle B LaPenna, Antonia Katsouda, John W Elrod, Josef Pfeilschifter, et al. 2023. “Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.”. Circulation Research 132 (2): 154-66.

BAG3: a new player in the heart failure paradigm.

Publication: Journal Article

Knezevic, Tijana, Valerie D Myers, Jennifer Gordon, Douglas G Tilley, Thomas E Sharp, JuFang Wang, Kamel Khalili, Joseph Y Cheung, and Arthur M Feldman. 2015. “BAG3: a New Player in the Heart Failure Paradigm.”. Heart Failure Reviews 20 (4): 423-34.

Combination Cell Therapy for Ischemic Cardiomyopathy: Is the Whole Greater Than Sum of Its Parts?

Publication: Journal Article

Recchia, Fabio A, and Thomas E Sharp. 2017. “Combination Cell Therapy for Ischemic Cardiomyopathy: Is the Whole Greater Than Sum of Its Parts?”. Journal of the American College of Cardiology 70 (20): 2516-18.

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.

Publication: Journal Article

LaPenna, Kyle B, Zhen Li, Jake E Doiron, Thomas E Sharp, Huijing Xia, Karl Moles, Kashyap Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a ‘2-Hit’ Murine Model.”. Journal of the American Heart Association 12 (4): e028480.

Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

Publication: Journal Article

Sharp, Thomas E, Giana J Schena, Alexander R Hobby, Timothy Starosta, Remus M Berretta, Markus Wallner, Giulia Borghetti, et al. 2017. “Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.”. Circulation Research 121 (11): 1263-78.

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.

Publication: Journal Article

Bradley, Jessica M, Pablo Spaletra, Zhen Li, Thomas E Sharp, Traci T Goodchild, Laura G Corral, Leah Fung, et al. 2018. “A Novel Fibroblast Activation Inhibitor Attenuates Left Ventricular Remodeling and Preserves Cardiac Function in Heart Failure.”. American Journal of Physiology. Heart and Circulatory Physiology 315 (3): H563-H570.

Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.

Publication: Journal Article

Organ, Chelsea L, Zhen Li, Thomas E Sharp, David J Polhemus, Nilaksh Gupta, Traci T Goodchild, W H Wilson Tang, Stanley L Hazen, and David J Lefer. 2020. “Nonlethal Inhibition of Gut Microbial Trimethylamine N-Oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.”. Journal of the American Heart Association 9 (10): e016223.

Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

Publication: Journal Article

Polhemus, David J, Rishi K Trivedi, Thomas E Sharp, Zhen Li, Traci T Goodchild, Amy Scarborough, Geoffrey de Couto, Eduardo Marbán, and David J Lefer. 2019. “Repeated Cell Transplantation and Adjunct Renal Denervation in Ischemic Heart Failure: Exploring Modalities for Improving Cell Therapy Efficacy.”. Basic Research in Cardiology 114 (2): 9.

Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.

Publication: Journal Article

Taghavi, Sharven, Thomas E Sharp, Jason M Duran, Catherine A Makarewich, Remus M Berretta, Tim Starosta, Hajime Kubo, Mary Barbe, and Steven R Houser. 2015. “Autologous C-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit As Compared to C-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.”. Clinical and Translational Science 8 (5): 425-31.