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Abstract Presented: "Ultrasound Renal Denervation Protects the Ischemic-Reperfused Myocardium in a swine Model of Hypertension and Dyslipidemia"

Dr. Sharp speaks at the 2025 American Heart Association, Basic Cardiovascular Sciences Scientific Session, Baltimore, MD. AHA BCVS is one of the largest meetings globally dedicated to fundamental and translational research in cardiovascular science. The BCVS Scientific Sessions is a unique and...

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in...

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle. Originally, light-to-moderate alcohol consumption was believed to provide some protective effects on the cardiovascular system through its antioxidant properties and other constituents; this was...

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and diastolic dysfunction. We utilized a systems-biology approach to...

Abstract Presented: "Gut Microbial Metabolite Phenylacetylglutamine Leads to Cardiomyocyte Hypercontractility and Vascular Endothelial Cell Activation."

Dr. Sharp speaks at the 2025 Inaugural USF Heart Institute Symposium. Talk entitled "Microbiota, Metabolites, and Myocardium: Cardiovascular Consequences of Alcohol-Induced Gut Dysbiosis"

The Sharp Laboratory has joined USF, Morsani College of Medicine, Department of Molecular Pharmacology and Physiology. We will reside at the downtown campus - USF MDD. We are also affiliated with the USFHealth Heart Institute. As the laboratory develops and grows we will seek exceptionally motivated...

Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study Acute myocardial infarction (AMI) patients typically present with a constellation of one or more risk factors including hypertension...

Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment Swine are increasingly utilized in cardiovascular research due to their anatomical and physiological similarities to humans, particularly for studying diastolic dysfunction. While...