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Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment Swine are increasingly utilized in cardiovascular research due to their anatomical and physiological similarities to humans, particularly for studying diastolic dysfunction. While...

The HFpEF Summit is a bi-annual, two-day meeting which brings together internationally recognized leaders in the areas of clinical, translational and biological studies of heart failure with preserved ejection fraction (HFpEF). This summit is focused on the latest insights and innovations for...

Dr. Sharp speaks at the 2025 HFpEF Summit, Beverly Hills, CA. A world-class summit which brings together internationally recognized experts discussing the preclinical and clinical findings in cardiometbolic disease and HF.

We are excited to welcome Trung to the Sharp Laboratory as a graduate student! Trung is a native Floridian, who received his undergradute degree from the University of Florida followed by a Master's from John's Hopkins University in Baltimore, MD. Trung has joined us as of Jan. 2024. Looking forward...

We are excited to welcome Kiersten to the Sharp Laboratory as an advanced research scientist! Kiersten is a native to Florida, who received her undergraduate degree from Cornell University. Kiersten has more than a decade of biomedical research experience. Kiersten has joined us as of Dec. 2023...

Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure with Preserved Ejection Fraction Aims - Overactivity of the sympathetic nervous system is a common underlying mechanism in development and progression of several heart failure with preserved...

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H 2S) bioavailability in HFpEF patients and 2 animal models: the "2-hit" L-NAME + high-fat...