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Sharp Laboratory - University South Florida

News: June 01, 2020

The Sharp Laboratory has joined USF, Morsani College of Medicine, Department of Molecular Pharmacology and Physiology. We will reside at the downtown campus - USF MDD. We are also affiliated with the USFHealth Heart Institute. As the laboratory develops and grows we will seek exceptionally motivated...

Common Heart Failure with Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics

Publication: Journal Article

Fenwick, AJ., VP. Jani, DB. Foster, TE. Sharp, TT. Goodchild, KB. LaPenna, JE. Doiron, et al. 2024. “Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics”. Journal of the American Heart Association.

Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns.

Publication: Journal Article

Sharp, Thomas E, David J Lefer, and Steven R Houser. 2019. “Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns.”. JACC. Basic to Translational Science 4 (3): 422-24.

Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

Publication: Journal Article

Doiron, Jake E, Huijing Xia, Xiaoman Yu, Alexandra R Nevins, Kyle B LaPenna, Thomas E Sharp, Traci T Goodchild, et al. 2024. “Adjunctive Therapy With an Oral H2S Donor Provides Additional Therapeutic Benefit Beyond SGLT2 Inhibition in Cardiometabolic Heart Failure With Preserved Ejection Fraction.”. British Journal of Pharmacology 181 (21): 4294-4310.

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.

Publication: Journal Article

Whitehead, Anna K, Nicholas D Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S Pearson, Kyle B LaPenna, Thomas E Sharp, et al. 2022. “Alpha7 Nicotinic Acetylcholine Receptor Mediates Chronic Nicotine Inhalation-Induced Cardiopulmonary Dysfunction.”. Clinical Science (London, England : 1979) 136 (12): 973-87.

Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.

Publication: Journal Article

Doiron, Jake E, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, W H Wilson Tang, Kyle B LaPenna, Thomas E Sharp, et al. 2024. “Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure With Preserved Ejection Fraction.”. BioRxiv : The Preprint Server for Biology.

Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

Publication: Journal Article

Sharp, Thomas E, Zhenwei Gong, Amy Scarborough, Eric S Goetzman, Murtuza J Ali, Pablo Spaletra, David J Lefer, Radhika H Muzumdar, and Traci T Goodchild. 2020. “Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.”. JACC. Basic to Translational Science 5 (7): 699-714.

Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.

Publication: Journal Article

Sharp, Thomas E, David J Polhemus, Zhen Li, Pablo Spaletra, Stephen Jenkins, John P Reilly, Christopher J White, Daniel R Kapusta, David J Lefer, and Traci T Goodchild. 2018. “Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.”. Journal of the American College of Cardiology 72 (21): 2609-21.

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

Publication: Journal Article

Toib, Amir, Chen Zhang, Giulia Borghetti, Xiaoxiao Zhang, Markus Wallner, Yijun Yang, Constantine D Troupes, et al. 2017. “Remodeling of Repolarization and Arrhythmia Susceptibility in a Myosin-Binding Protein C Knockout Mouse Model.”. American Journal of Physiology. Heart and Circulatory Physiology 313 (3): H620-H630.

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.

Publication: Journal Article

Li, Zhen, Chelsea L Organ, Jianming Kang, David J Polhemus, Rishi K Trivedi, Thomas E Sharp, Jack S Jenkins, Ya-Xiong Tao, Ming Xian, and David J Lefer. 2018. “Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.”. JACC. Basic to Translational Science 3 (6): 796-809.