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2025 JACC: Basic to Translational Science - ARTICLE

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and diastolic dysfunction. We utilized a systems-biology approach to...

Adam Khater

Adam Khater graduated with a BA in Chemistry from Grinnell College. He played middle linebacker for Grinnell College Football and was a member of the chess club. Adam's undergraduate research was a synthetic methodology optimizing the functionalization of 6-subtituted tryptamine derivatives, a...

2025 JACC: Basic to Translational Science - ARTICLE

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H 2S) bioavailability in HFpEF patients and 2 animal models: the "2-hit" L-NAME + high-fat...

New Publication in The Ocular Surface!

This brand-new publication from the Swamynathan laboratory, spearheaded by Mehak Vohra and Simran Kumar, was supported by the rest of the team. In this paper, they used a novel mouse model and a variety of different assays to elucidate that the apicobasal polarity determinant Pard3 promotes corneal...