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2024 Nature Communications - ARTICLE

News: December 30, 2024

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in...

2025 JACC: Basic to Translational Science - ARTICLE

News: August 18, 2025

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and diastolic dysfunction. We utilized a systems-biology approach to...

Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction.

Publication: Journal Article

Doiron, Jake E, Zhen Li, Xiaoman Yu, Kyle B LaPenna, Heather Quiriarte, Timothy D Allerton, Kashyap Koul, et al. 2024. “Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction.”. Journal of the American Heart Association 13 (4): e032646.

Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.

Publication: Journal Article

Jani, Vivek P, Navid Koleini, Axel J Fenwick, Thomas E Sharp, Traci T Goodchild, Joseph A Hill, David J Lefer, Anthony Cammarato, and David A Kass. 2024. “Cardiomyocyte Myofilament Function in Common Animal Models of Heart Failure With Preserved Ejection Fraction.”. Journal of Molecular and Cellular Cardiology 197: 34-39.

Sorafenib cardiotoxicity increases mortality after myocardial infarction.

Publication: Journal Article

Duran, Jason M, Catherine A Makarewich, Danielle Trappanese, Polina Gross, Sharmeen Husain, Jonathan Dunn, Hind Lal, et al. 2014. “Sorafenib Cardiotoxicity Increases Mortality After Myocardial Infarction.”. Circulation Research 114 (11): 1700-1712.

Stem cell therapy and breast cancer treatment: review of stem cell research and potential therapeutic impact against cardiotoxicities due to breast cancer treatment.

Publication: Journal Article

Sharp, Thomas E, and Jon C George. 2014. “Stem Cell Therapy and Breast Cancer Treatment: Review of Stem Cell Research and Potential Therapeutic Impact Against Cardiotoxicities Due to Breast Cancer Treatment.”. Frontiers in Oncology 4: 299.

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle.

Publication: Journal Article

Sharp, Thomas E, and Thanh Trung Van. 2024. “Thromboxane A2 Blockade Attenuates Ethanol-Induced Myocardial Inflammation: Sipping from the Same Bottle.”. Alcohol, Clinical & Experimental Research 48 (10): 1834-36.

A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function.

Publication: Journal Article

Wallner, Markus, Deborah M Eaton, Remus M Berretta, Giulia Borghetti, Jichuan Wu, Sandy T Baker, Eric A Feldsott, et al. 2017. “A Feline HFpEF Model With Pulmonary Hypertension and Compromised Pulmonary Function.”. Scientific Reports 7 (1): 16587.

Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.

Publication: Journal Article

Xia, Huijing, Zhen Li, Thomas E Sharp, David J Polhemus, Jean Carnal, Karl H Moles, Ya-Xiong Tao, et al. 2020. “Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.”. Journal of the American Heart Association 9 (19): e017544.

Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms.

Publication: Journal Article

Duran, Jason M, Catherine A Makarewich, Thomas E Sharp, Timothy Starosta, Fang Zhu, Nicholas E Hoffman, Yumi Chiba, et al. 2013. “Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction through Transdifferentiation and Paracrine Signaling Mechanisms.”. Circulation Research 113 (5): 539-52.