About the Ma Lab
Understanding How the Immune System Heals the Heart
We aim to uncover the cellular and molecular mechanisms by which innate and adaptive immune cells regulate cardiac repair following myocardial infarction. By studying immune responses during inflammation, wound healing, and cardiac remodeling, we seek to develop innovative immunotherapies that improve recovery and prevent the progression to ischemic heart failure.
Methodology
We use clinically relevant mouse models of myocardial infarction (MI) combined with immunological, molecular, and imaging approaches to investigate the mechanisms that regulate cardiac injury and repair. Our work integrates flow cytometry, transcriptomics, histology, and functional cardiac assessments to define immune cell behavior following heart attack.
Lab Protocol
From animal models and immune profiling to molecular analyses and cardiac phenotyping, our research is guided by standardized protocols and best practices that promote accuracy, reproducibility, and innovation.
Translational Impact
Our goal is to bridge fundamental immunology and cardiovascular medicine by identifying immune mechanisms that can be targeted therapeutically. By translating basic discoveries into clinical opportunities, we aim to improve recovery and long-term outcomes after myocardial infarction.
Education
We are committed to providing a collaborative and supportive research environment. We currently have undergraduate students, graduate students, postdoctoral fellows, and technicians in our lab. Our laboratory emphasizes scientific rigor, mentorship, and professional development in cardiovascular research.
Funding
NIH-NHLBI (R01HL164446): 2022-Present
T lymphopenia in ischemic heart failure
PI: Yonggang Ma
NIH-NHLBI (T32HL160529): 2026-2027