Exploring the Toxicity of Betainized Polyethyleneimine

Our lab's leadership has recently published novel findings regarding our pan-antimicrobial betainized polyethyleneimine solution: https://www.mdpi.com/2227-9059/12/11/2462. We look into the cytotoxicity associated with our solution. 

Cytotoxicity of L929 fibroblasts in the presence of (a) PEI, PEI-CA, PEI-BA, and PEI-HCl, or (b) their betainized forms, B-PEI, B-PEI-CA, B-PEI-BA, and B-PEI-HCl solutions, for a 24 h incubation time up to 1000 μg/mL. (c) Light microscope images of the cells interacting with PEI, PEI-BA, B-PEI, and B-PEI-BA solutions at a 1000 μg/mL concentration and without any materials as the control group. The results were determined as statistically significant for p-values of * p < 0.05 and ** p < 0.001 vs. control.