Dr. Jerome Breslin

My research program explores the cellular and molecular mechanisms by which the microcirculation and lymphatic vessels control tissue and organ homeostasis. We are currently funded by the NIH to study three specific topics: 1) How endothelial-protective bioactive lipids such as sphingosine-1-phosphate protect the microcirculation and reduce leukocyte rolling/adhesion/infiltration caused by hemorrhagic shock or traumatic injury; 2) Mechanisms of sigma receptor-mediated arterial vasodilation and variations in the human population; and 3) the impact of metabolic syndrome on the complex relationship between lymphatic vessels and adipose tissue. We use a variety of approaches using cell culture, animal models, and human organ/tissue models. Trainees in my laboratory get to work with top experts in our field and are provided ample opportunities for presentations and networking to ensure future success in a career in academia, industry, or government.