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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).

Publication: Journal Article

Gibb, Andrew A, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Carmen Choya-Foces, Jake E Doiron, et al. 2024. “Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism As Key Contributors to Heart Failure With Preserved Ejection Fraction (HFpEF).”. BioRxiv : The Preprint Server for Biology.

Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

Publication: Journal Article

Mohsin, Sadia, Constantine D Troupes, Timothy Starosta, Thomas E Sharp, Elorm J Agra, Shavonn Smith, Jason M Duran, et al. 2015. “Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.”. Circulation Research 117 (12): 1024-33.

2025 AHA BCVS - CONFERENCE: Dr. Sharp speaks on Renal Denervation to Treat Heart Failure

News: July 23, 2025

Dr. Sharp speaks at the 2025 American Heart Association, Basic Cardiovascular Sciences Scientific Session, Baltimore, MD. AHA BCVS is one of the largest meetings globally dedicated to fundamental and translational research in cardiovascular science. The BCVS Scientific Sessions is a unique and...

2025 Circulation Research - ARTICLE

News: September 17, 2025

Background: Recent studies suggest aberrant elevation of iNOS (inducible NO synthase) expression and excessive protein s-nitrosylation promote the pathogenesis of heart failure with preserved ejection fraction (HFpEF). However, the interplay between NO bioavailability, enzymatic regulation of...

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.

Publication: Journal Article

Li, Zhen, Huijing Xia, Thomas E Sharp, Kyle B LaPenna, John W Elrod, Kevin M Casin, Ken Liu, et al. 2022. “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.”. Circulation Research 131 (3): 222-35.

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet.

Publication: Journal Article

Whitehead, Anna K, Zhen Li, Kyle B LaPenna, Nour Abbes, Thomas E Sharp, David J Lefer, Eric Lazartigues, and Xinping Yue. 2024. “Cardiovascular Dysfunction Induced by Combined Exposure to Nicotine Inhalation and High-Fat Diet.”. American Journal of Physiology. Heart and Circulatory Physiology 326 (1): H278-H290.

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Publication: Journal Article

Wallner, Markus, Jason M Duran, Sadia Mohsin, Constantine D Troupes, Davy Vanhoutte, Giulia Borghetti, Ronald J Vagnozzi, et al. 2016. “Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.”. Circulation Research 119 (7): 865-79.

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

Publication: Journal Article

Li, Zhen, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S Li, et al. 2024. “Alcohol-Induced Gut Microbial Reorganization and Associated Overproduction of Phenylacetylglutamine Promotes Cardiovascular Disease.”. Nature Communications 15 (1): 10788.

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.

Publication: Journal Article

Lefer, David J, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah, Zhen Li, and Traci T Goodchild. 2025. “Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure With Preserved Ejection Fraction.”. European Journal of Heart Failure.

Thomas E. Sharp, III

Person: Principal Investigator

Tom is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the USF Morsani College of Medicine and a faculty member of the USF Health Heart Institute in Tampa, Florida, USA. He earned his Ph.D. from Temple University’s Lewis Katz School of Medicine, where he was...