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Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

Publication: Journal Article

Polhemus, David J, Rishi K Trivedi, Thomas E Sharp, Zhen Li, Traci T Goodchild, Amy Scarborough, Geoffrey de Couto, Eduardo Marbán, and David J Lefer. 2019. “Repeated Cell Transplantation and Adjunct Renal Denervation in Ischemic Heart Failure: Exploring Modalities for Improving Cell Therapy Efficacy.”. Basic Research in Cardiology 114 (2): 9.

Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.

Publication: Journal Article

Taghavi, Sharven, Thomas E Sharp, Jason M Duran, Catherine A Makarewich, Remus M Berretta, Tim Starosta, Hajime Kubo, Mary Barbe, and Steven R Houser. 2015. “Autologous C-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit As Compared to C-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.”. Clinical and Translational Science 8 (5): 425-31.

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.

Publication: Journal Article

Li, Zhen, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, Jake E Doiron, Huijing Xia, et al. 2024. “Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure With Preserved Ejection Fraction.”. BioRxiv : The Preprint Server for Biology.

2025 Inaugural USF Heart Institute Symposium: Dr. Sharp Speaks on Gut-derived metabolites & CVD

News: May 15, 2025

Dr. Sharp speaks at the 2025 Inaugural USF Heart Institute Symposium. Talk entitled "Microbiota, Metabolites, and Myocardium: Cardiovascular Consequences of Alcohol-Induced Gut Dysbiosis"

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.

Publication: Journal Article

Li, Zhen, Huijing Xia, Thomas E Sharp, Kyle B LaPenna, John W Elrod, Kevin M Casin, Ken Liu, et al. 2022. “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.”. Circulation Research 131 (3): 222-35.

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet.

Publication: Journal Article

Whitehead, Anna K, Zhen Li, Kyle B LaPenna, Nour Abbes, Thomas E Sharp, David J Lefer, Eric Lazartigues, and Xinping Yue. 2024. “Cardiovascular Dysfunction Induced by Combined Exposure to Nicotine Inhalation and High-Fat Diet.”. American Journal of Physiology. Heart and Circulatory Physiology 326 (1): H278-H290.

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Publication: Journal Article

Wallner, Markus, Jason M Duran, Sadia Mohsin, Constantine D Troupes, Davy Vanhoutte, Giulia Borghetti, Ronald J Vagnozzi, et al. 2016. “Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.”. Circulation Research 119 (7): 865-79.

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

Publication: Journal Article

Li, Zhen, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S Li, et al. 2024. “Alcohol-Induced Gut Microbial Reorganization and Associated Overproduction of Phenylacetylglutamine Promotes Cardiovascular Disease.”. Nature Communications 15 (1): 10788.

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.

Publication: Journal Article

Lefer, David J, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah, Zhen Li, and Traci T Goodchild. 2025. “Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure With Preserved Ejection Fraction.”. European Journal of Heart Failure.

Thomas E. Sharp, III

Person: Principal Investigator

Tom is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the USF Morsani College of Medicine and a faculty member of the USF Health Heart Institute in Tampa, Florida, USA. He earned his Ph.D. from Temple University’s Lewis Katz School of Medicine, where he was...