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Validation of transcatheter left ventricular electromechanical mapping for assessment of cardiac function and targeted transendocardial injection in a porcine ischemia-reperfusion model.

Publication: Journal Article

Taghavi, Sharven, Jason M Duran, Remus M Berretta, Catherine A Makarewich, Foram Udeshi, Thomas E Sharp, Hajime Kubo, Steven R Houser, and Jon C George. 2012. “Validation of Transcatheter Left Ventricular Electromechanical Mapping for Assessment of Cardiac Function and Targeted Transendocardial Injection in a Porcine Ischemia-Reperfusion Model.”. American Journal of Translational Research 4 (2): 240-6.

2025 HFpEF Summit: Dr. Sharp speaks on RDN in preclinical models of HFpEF

News: March 20, 2025

Dr. Sharp speaks at the 2025 HFpEF Summit, Beverly Hills, CA. A world-class summit which brings together internationally recognized experts discussing the preclinical and clinical findings in cardiometbolic disease and HF.

2025 European Journal of Heart Failure - ARTICLE: Short Report

News: May 22, 2025

"Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure with Preserved Ejection Fraction" Aims - Overactivity of the sympathetic nervous system is a common underlying mechanism in development and progression of several heart failure with preserved...

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.

Publication: Journal Article

Li, Zhen, Huijing Xia, Thomas E Sharp, Kyle B LaPenna, John W Elrod, Kevin M Casin, Ken Liu, et al. 2022. “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure.”. Circulation Research 131 (3): 222-35.

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet.

Publication: Journal Article

Whitehead, Anna K, Zhen Li, Kyle B LaPenna, Nour Abbes, Thomas E Sharp, David J Lefer, Eric Lazartigues, and Xinping Yue. 2024. “Cardiovascular Dysfunction Induced by Combined Exposure to Nicotine Inhalation and High-Fat Diet.”. American Journal of Physiology. Heart and Circulatory Physiology 326 (1): H278-H290.

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Publication: Journal Article

Wallner, Markus, Jason M Duran, Sadia Mohsin, Constantine D Troupes, Davy Vanhoutte, Giulia Borghetti, Ronald J Vagnozzi, et al. 2016. “Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.”. Circulation Research 119 (7): 865-79.

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

Publication: Journal Article

Li, Zhen, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S Li, et al. 2024. “Alcohol-Induced Gut Microbial Reorganization and Associated Overproduction of Phenylacetylglutamine Promotes Cardiovascular Disease.”. Nature Communications 15 (1): 10788.

2024 Nature Communications - ARTICLE

News: December 30, 2024

"Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease" The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation...

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.

Publication: Journal Article

Lefer, David J, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah, Zhen Li, and Traci T Goodchild. 2025. “Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure With Preserved Ejection Fraction.”. European Journal of Heart Failure.

Thomas E. Sharp, III

Person: Principal Investigator

Tom is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the USF Morsani College of Medicine and a faculty member of the USF Health Heart Institute in Tampa, Florida, USA. He earned his Ph.D. from Temple University’s Lewis Katz School of Medicine, where he was...