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Early Renal Denervation Attenuates Cardiorenal Dysfunction in Heart Failure with Preserved Ejection Fraction

Publication: Journal Article

Doiron, JE., Z. Li, TE. Sharp, KB. LaPenna, K. Koul, AJ. Malek, SJ. Shah, et al. 2024. “Early Renal Denervation Attenuates Cardiorenal Dysfunction in Heart Failure With Preserved Ejection Fraction”. Journal of the American Heart Association.

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure

Publication: Journal Article

Li, Z., H. Xia, TE. Sharp, KB. LaPenna, JW. Elrod, JW. Calvert, FN. Salloumn, et al. 2022. “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure”. Circulation Research.

Adjunctive Therapy with an Oral H2S Donor Provides Additional Therapeutic Benefit Beyond SGLT2 Inhibition in Cardiometabolic HFpEF

Publication: Journal Article

Doiron, JE., H. Xio, X. Yu, AR. Nevins, KB. LaPenna, TE. Sharp, TT. Goodchild, et al. 2024. “Adjunctive Therapy With an Oral H2S Donor Provides Additional Therapeutic Benefit Beyond SGLT2 Inhibition in Cardiometabolic HFpEF”. British Journal of Pharmacology.

2024 CARDIOVASCULAR RESEARCH FOUNDATION TCT Conference

News: October 28, 2024

Abstract Presented: "Ultrasound Renal Denervation Protects the Ischemic-Reperfused Myocardium in a swine Model of Hypertension and Dyslipidemia"

Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia

Publication: Journal Article

Sukhanov, S., Y. Higashi, T. Yoshida, S. Danchuk, M. Alfortish, TT. Goodchild, A. Scarborough, and TE. Sharp. 2023. “Insulin-Like Growth Factor 1 Reduces Coronary Atherosclerosis in Pigs With Familial Hypercholesterolemia”. JCI Insight.

Kiersten Gorse

Person: Advanced Research Scientist

Kiersten J. Gorse, B.S. Kiersten is an advanced research scientist in the Sharp laboratory at USF Morsani College of Medicine in Tampa, Florida, USA. Kiersten received her bachelor degree from Cornell University where she majored in animal sciences. She has more than a decade of biomedical research...

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2024 Alcohol: Clinical & Experimental Research - COMMNETARY

News: August 14, 2024

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle. Originally, light-to-moderate alcohol consumption was believed to provide some protective effects on the cardiovascular system through its antioxidant properties and other constituents; this was...

Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a "Two-Hit" Murine Model

Publication: Journal Article

LaPenna, KB., Z. Li, JE. Doiron, TE. Sharp, H. Xia, K. Moles, K. Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a ‘Two-Hit’ Murine Model”. Journal of the American Heart Association.

Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure

Publication: Journal Article

Li, Z., H. Xia, TE. Sharp, KB. LaPenna, A. Katsouda, JW. Elrod, J. Pfeilschifter, et al. 2023. “Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure”. Circulation Research.