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Novel Gottingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities

Publication: Journal Article

Sharp, TE., A. Scarborough, Z. Li, DJ. Polhemus, H. Hidalgo, JD. Schumacher, TR. Matsuura, et al. 2022. “Novel Gottingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities”. JACC: Basic to Translational Science.

2024 AMERICAN HEART ASSOCIATION Basic Cardiovascular (BCVS) Scientific Sessions

News: July 22, 2024

Abstract Presented: "Gut Microbial Metabolite Phenylacetylglutamine Leads to Cardiomyocyte Hypercontractility and Vascular Endothelial Cell Activation."

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We are located in the USF Health Heart Institute at the University of South Florida, Morsani College of Medicine, Tampa, FL. Our academic affiliation is in the Department of Molecular Pharmacology and Physiology. Our laboratory is focused on discovery-based, hypothesis-driven biomedical research...

Sharp Lab

Welcome Kiersten Gorse! Adv. Research Scientist in the Sharp Laboratory

News: December 20, 2023

We are excited to welcome Kiersten to the Sharp Laboratory as an advanced research scientist! Kiersten is a native to Florida, who received her undergraduate degree from Cornell University. Kiersten has more than a decade of biomedical research experience. Kiersten has joined us as of Dec. 2023...

Welcome Thahn Trung Van! New Graduate Student in the Sharp Laboratory

News: January 01, 2024

We are excited to welcome Trung to the Sharp Laboratory as a graduate student! Trung is a native Floridian, who received his undergradute degree from the University of Florida followed by a Master's from John's Hopkins University in Baltimore, MD. Trung has joined us as of Jan. 2024. Looking forward...

Doiron, Jake E, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, W H Wilson Tang, Kyle B LaPenna, Thomas E Sharp, et al. 2024. “Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure With Preserved Ejection Fraction.”. BioRxiv : The Preprint Server for Biology.

Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.