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Novel Gottingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities

Publication: Journal Article

Sharp, TE., A. Scarborough, Z. Li, DJ. Polhemus, H. Hidalgo, JD. Schumacher, TR. Matsuura, et al. 2022. “Novel Gottingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities”. JACC: Basic to Translational Science.

2024 AMERICAN HEART ASSOCIATION Basic Cardiovascular (BCVS) Scientific Sessions

News: July 22, 2024

Abstract Presented: "Gut Microbial Metabolite Phenylacetylglutamine Leads to Cardiomyocyte Hypercontractility and Vascular Endothelial Cell Activation."

About

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We are located in the USF Health Heart Institute at the University of South Florida, Morsani College of Medicine, Tampa, FL. Our academic affiliation is in the Department of Molecular Pharmacology and Physiology. Our laboratory is focused on discovery-based, hypothesis-driven biomedical research...

Sharp Lab

Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia

Publication: Journal Article

Sukhanov, S., Y. Higashi, T. Yoshida, S. Danchuk, M. Alfortish, TT. Goodchild, A. Scarborough, and TE. Sharp. 2023. “Insulin-Like Growth Factor 1 Reduces Coronary Atherosclerosis in Pigs With Familial Hypercholesterolemia”. JCI Insight.

Kiersten Gorse

Person: Advanced Research Scientist

Kiersten J. Gorse, B.S. Kiersten is an advanced research scientist in the Sharp laboratory at USF Morsani College of Medicine in Tampa, Florida, USA. Kiersten received her bachelor degree from Cornell University where she majored in animal sciences. She has more than a decade of biomedical research...

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2024 Alcohol: Clinical & Experimental Research - COMMNETARY

News: August 14, 2024

Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle. Originally, light-to-moderate alcohol consumption was believed to provide some protective effects on the cardiovascular system through its antioxidant properties and other constituents; this was...

Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a "Two-Hit" Murine Model

Publication: Journal Article

LaPenna, KB., Z. Li, JE. Doiron, TE. Sharp, H. Xia, K. Moles, K. Koul, et al. 2023. “Combination Sodium Nitrite and Hydralazine Therapy Attenuates HFpEF Severity in a ‘Two-Hit’ Murine Model”. Journal of the American Heart Association.

Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure

Publication: Journal Article

Li, Z., H. Xia, TE. Sharp, KB. LaPenna, A. Katsouda, JW. Elrod, J. Pfeilschifter, et al. 2023. “Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure”. Circulation Research.