News + Updates

Background: Recent studies suggest aberrant elevation of iNOS (inducible NO synthase) expression and excessive protein s-nitrosylation promote the pathogenesis of heart failure with preserved...

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic...

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF

Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen...

Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study

Acute myocardial infarction (AMI)...

Dr. Sharp speaks at the 2025 American Heart Association, Basic Cardiovascular Sciences Scientific Session, Baltimore, MD. 

AHA BCVS is one of the largest meetings globally dedicated to fundamental...

Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure with Preserved Ejection Fraction

Aims - Overactivity of the sympathetic nervous system is a...

Dr. Sharp speaks at the 2025 Inaugural USF Heart Institute Symposium. Talk entitled "Microbiota, Metabolites, and Myocardium: Cardiovascular Consequences of Alcohol-Induced Gut Dysbiosis"

Dr. Sharp speaks at the 2025 HFpEF Summit, Beverly Hills, CA. A world-class summit which brings together internationally recognized experts discussing the preclinical and clinical findings in...

Comprehensive Echocardiographic Protocol for Pigs with Emphasis on Diastolic Function: Advantages over MRI Assessment

Swine are increasingly utilized in cardiovascular research due to their...

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease

The mechanism(s) underlying gut microbial metabolite (GMM)...