Research
Featured Research Areas
Laminin and Laminin Receptors in BBB Maintenance
Laminin is a trimeric protein with many isoforms. Interestingly, different cell types synthesize distinct laminin isoforms. By binding to their receptors, different laminin isoforms differentially regulate BBB integrity. Specifically, astrocytic laminin actively maintains BBB integrity...
Laminin and Laminin Receptors in Neurological Disorders
Based on the important functions of laminin and its receptors in BBB maintenance, we hypothesize that laminin signaling may affect the pathogenesis and outcomes of various neurological disorders, including stroke (both hemorrhagic and ischemic) and Alzheimer’s disease. We have recently shown that...
Pericyte and Fibroblast Biology in the CNS
Pericytes and fibroblasts are two less studied cell populations in the CNS. Their biology and functions under physiological and pathological conditions are largely unclear. By using novel genetic models, we are able to selectively ablate these cells. We are characterizing the phenotypes of the resulting mice with or without brain injury and exploring the underlying molecular mechanisms. These findings will uncover the functional significance of pericytes and fibroblasts in brain homeostasis and neurological disorders.
Lighting the way
Forefront of BBB and ECM Research
At Yao's lab, we have provided a friendly, interactive and constructive environment where everyone can enjoy doing neuroscience research and progress with their academic journey.
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