Yao, Yao. 2023. NR4A1 Destabilizes TNF MRNA in Microglia and Modulates Stroke Outcomes.
Abstract
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.